http://sciencecareers.sciencemag.org/funding/funding_news Here are the top science research and funding opportunities from this month's Funding News, compliments of GrantsNet http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5292 Our reasons for inviting proposals on these topics are as follows: Available data indicate that nearly 7.4 million persons are engaged in science and engineering (SandE) occupations, representing about 5% of the civilian U.S. workforce of 147 million. Though a rather small percentage of the total, this SandE workforce is very highly skilled, and many are engaged in leading-edge research and development activities that are critical to the future economic well-being of the United States. In addition, a similar percentage of U.S. workers have earned at least bachelor's degrees in SandE fields but are employed in non-SandE occupations; rather little is known about the latter category. We believe that much could be gained from an improved understanding of the U.S. SandE workforce in relation to the domestic and international labor markets in which it operates. These subjects have long attracted a great deal of rhetorical and political commentary, yet objective research attention has been limited by the difficulty of obtaining needed grant funding. 2008-11-17 http://grantsnet.org/search/pgm_info.cfm?pgm_id=4208 The Alzheimer's Drug Discovery Foundation (ADDF) and the Association for Frontotemporal Dementias (AFTD) seek proposals to accelerate and support drug discovery for FTD and related dementias. Examples of programs appropriate for this request for proposals include, but are not limited to, identification and in vitro testing of potentially disease-modifying lead compounds; development and testing of novel high-throughput screening assays; medicinal chemistry on lead compounds; testing of lead compounds in a relevant animal model for preclinical proof of concept; ADME, toxicology, pharmacokinetics, and pharmacodynamics on lead compounds; development and testing of targeted gene-delivery strategies; and development of biomarkers to accelerate drug development and early diagnosis. Please note: this funding will not support applications for basic research. ADDF/AFTD will provide individual grants of a 1-year duration, with the possibility of follow-on funding. Applications may be submitted by nonprofit academic institutions and for-profit biotechnology companies, both public and private, worldwide. Collaborative teams of neuroscientists and researchers in drug-discovery disciplines such as medicinal chemistry and drug delivery are also encouraged to apply. 2008-09-22 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5291 The Amyotrophic Lateral Sclerosis (ALS) Association and the American Academy of Neurology (AAN) Foundation have announced a 3-year Clinician-Scientist Development Award to support research into drug discovery and development of therapies that will effectively treat ALS. The award was developed as part of the ALS Association's research program TREAT ALS (Translational Research Advancing Therapy for ALS). The AAN Foundation/ALS Association Clinician-Scientist Development Award aims to recognize the importance of good clinical research and encourage young investigators in clinical studies. The 3-year award will consist of an annual salary of $75,000, plus a $5000 institutional award. To be eligible, an applicant must be a neurologist interested in an academic career in clinical research. Applicants must hold an M.D., a D.O., or an equivalent degree from an accredited institution and be licensed to practice medicine in the United States. Applicants must have completed residency training but be less than 7 years from completion of residency when funding begins. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5244 The American Council of Learned Societies (ACLS) Fellowship Program invites research applications in all disciplines of the humanities and humanities-related social sciences. The ultimate goal of the project should be a major piece of scholarly work by the applicant that will take the form of a monograph or other equally substantial form of scholarship. ACLS does not fund creative work (e.g., novels or films), textbooks, straightforward translation, or pedagogical projects. 2008-10-02 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5246 The American Council of Learned Societies (ACLS) invites applications for the seventh annual competition for the Charles A. Ryskamp Research Fellowships, generously funded by the Andrew W. Mellon Foundation in honor of Charles A. Ryskamp, literary scholar, distinguished library and museum director, and long-serving trustee of the foundation. These fellowships support advanced assistant professors and untenured associate professors in the humanities and related social sciences whose scholarly contributions have advanced their fields and who have well-designed and carefully developed plans for new research. The fellowships are intended to provide time and resources to enable these faculty members to conduct their research under optimal conditions. The ultimate goal of the project should be a major piece of scholarly work by the applicant that will take the form of a monograph or other equally substantial form of scholarship. ACLS does not fund creative work (e.g., novels or films), textbooks, straightforward translation, or pedagogical projects. 2008-10-02 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5253 The American Council of Learned Societies (ACLS) invites applications for the ninth annual competition for the Frederick Burkhardt Residential Fellowships for Recently Tenured Scholars, owing to the generous assistance of the Andrew W. Mellon Foundation. The fellowships are named for Frederick Burkhardt, president emeritus of ACLS, whose decades of work on The Correspondence of Charles Darwin constitute a signal example of dedication to a demanding and ambitious scholarly enterprise. These fellowships support long-term, unusually ambitious projects in the humanities and related social sciences. The ultimate goal of the project should be a major piece of scholarly work by the applicant that will take the form of a monograph or other equally substantial form of scholarship. ACLS does not fund creative work (e.g., novels or films), textbooks, straightforward translation, or pedagogical projects. 2008-10-02 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=4339 The American Council of Learned Societies invites applications for the third annual competition for the ACLS Digital Innovation Fellowships. Funded by the Andrew W. Mellon Foundation, this program supports digitally based research projects in all disciplines of the humanities and humanities-related social sciences. It is hoped that funded projects will help advance digital humanistic scholarship by broadening understanding of its nature and exemplifying the robust infrastructure necessary for creating further such works. Fellowships are intended to support an academic year dedicated to work on a major scholarly project that takes a digital form. Projects may involve development of new digital tools that further humanistic research; research that depends on or is greatly enhanced by the use of such tools; the representation of research that depends on or is greatly enhanced by the use of such tools; or some combination of these features. ACLS does not support creative works (e.g., novels or films), textbooks, straightforward translations, or purely pedagogical projects. 2008-10-02 http://grantsnet.org/search/pgm_info.cfm?pgm_id=4210 The American Kidney Fund is pleased to invite applications to its Clinical Scientist in Nephrology (CSN) program for academic year 2009–10. The goal of the CSN program is to improve the quality of care provided to kidney patients and to promote clinical research in nephrology. This goal is achieved by enhancing the training of nephrologists who desire to pursue an academic career and whose primary professional commitment is to scholarship in the provision of patient care. Awardees conduct prevention and outcomes research and receive advanced training in essential skills such as medical ethics, biostatistics, and epidemiology. 2008-12-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=4259 The Charles H. Hood Foundation was incorporated in 1942 to improve the health and quality of life for children through grant support of New England–based pediatric researchers. The foundation's emphasis is on the initiation and furtherance of medical research that will help to diminish health problems affecting large numbers of children. Grants must have direct relevance to pediatric diseases. The intent of the award is to support initial independent investigations, provide the opportunity to demonstrate creativity, and assist in the transition to other sources of research funding. 2008-09-16 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=3732 Initial Ph.D. Postdoc, Advanced Ph.D. Postdoc, Initial M.D. Postdoc, Advanced M.D. Postdoc, Junior Faculty, Senior Scientist/Faculty Program Description: The Reeve Foundation funds activities that hold promise of identifying therapies for paralysis caused by spinal cord injury and other sequelae of central nervous system injury. The areas of research listed below are the focus of current Reeve Foundation emphasis and funding: FUNDING PRIORITIES: * studying strategies that may promote neuronal growth and survival, encourage the formation of synapses, enhance the production of myelin, restore conduction capabilities, or may otherwise lead to restoration of the compromised circuitry in the acutely and chronically injured spinal cord; * evaluating the efficacy of drugs or other interventions that protect against secondary neuronal injury or provide insight into the mechanisms causing such damage; * defining anatomical characteristics of spinal cord injury in well-defined animal models and in the human spinal cord, specifically documenting the neuronal systems that are most vulnerable to spinal cord injury and the functional losses occurring as a result; and * elucidating the biological mechanisms underlying approaches to improve concomitant functions affected by spinal cord injury (e.g., bladder function, sexual function) and alleviate chronic pain and spasticity. The development of treatments for chronic injury is a high priority for the organization; however, funding will also be provided for studies more relevant to the acute phase of injury. Basic research will be supported if it has clear potential to accelerate progress at the applied end of the continuum and/or if it reflects a research "change of direction." 2008-12-15 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5303 The purpose of this funding opportunity announcement is to solicit applications to develop new and improved technologies for obtaining samples of individual microbial isolates or strains, from the human microbiota, suitable for complete genomic sequence analysis. The goal is to expand the number of "reference" microbial genome sequences, which in turn will aid in the analysis of the complex microbial populations resident in and on the human body. 2008-09-02 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5304 The purpose of this funding opportunity announcement is to solicit applications to develop new and improved technologies for obtaining samples of individual microbial isolates or strains, from the human microbiota, suitable for complete genomic sequence analysis. The goal is to expand the number of "reference" microbial genome sequences, which in turn will aid in the analysis of the complex microbial populations resident in and on the human body. 2008-09-02 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5302 The National Institutes of Health invites research applications to develop and evaluate in a large-scale screening-center environment innovative instrumentation to accelerate the pace and maximize the efficiency of small molecule high-throughput screening. Grantees are encouraged to utilize one of the Molecular Libraries Probe Production Centers Network centers for installation and testing the instrumentation to implement one or more screens. The applicants can also propose to use other suitable screening centers for this purpose. 2008-09-02 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5225 This funding opportunity announcement solicits Research and Development Center (P30) grant applications in the areas of demography and economics of aging, including relevant interdisciplinary areas rooted in population-based social science research. Center grant applications must include two mandatory cores and may choose among four optional cores. 2008-09-30 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5299 The purpose of this funding opportunity is to support research that will test explicitly identified assumptions and hypotheses that undergird existing or potential interventions intended to increase interest, motivation, and preparedness for careers in biomedical and behavioral research, with a particular interest in those interventions specifically designed to increase the number of students from underrepresented groups entering careers in biomedical and behavioral research. The proposed research need not be restricted to underrepresented minority students. Comparative research that analyzes the experience of all groups in order to place that of underrepresented students in context and to learn whether and how interventions should be tailored to make more underrepresented students successful in biomedical careers may well be particularly illuminating and is, therefore, encouraged. 2008-09-30 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5243 This funding opportunity announcement is for projects from individual investigators or small groups to collaborate with the National Institutes of Health Roadmap for Medical Research National Centers for Biomedical Computing (NCBC). The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. 2008-10-25 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5282 The purpose of this funding opportunity announcement (FOA) is to stimulate investigations in the area of Social Neuroscience of Aging.?The National Institute on Aging (NIA) invites R01 applications for research examining the neurobiological and genetic foundations and correlates of social behaviors and social relationships of relevance to aging, with particular emphasis on the mechanisms and pathways linking social behaviors and social relationships to the physical health, functionality, and psychological well-being of middle-aged and older adults. The NIA is interested in both basic and translational research on these topics, and strongly encourages applications that explore these themes at multiple levels of analysis. Both human and animal studies are appropriate to this FOA. Research projects that (1) link the social neuroscience laboratory with population-based research, (2) cross traditional disciplinary barriers within the biological and behavioral sciences, or (3) offer bridges to translational efforts to improve social function and enhance social roles in older adults are particularly encouraged. There is the strong expectation that applications in response to this FOA will support new lines of research by interdisciplinary teams. 2008-09-30 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5279 The National Institute of Mental Health (NIMH) invites applications for Silvio O. Conte Centers for Basic and Translational Mental Health Research. The institute seeks teams of researchers working at different levels of analysis and engaging in integrative, novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objective of: (a) advancing the state of the science in brain and behavior research relevant to mental health; (b) supporting the integration and translation of basic and clinical neuroscience research on severe mental illnesses; and/or (c) advancing our understanding of the neurobehavioral developmental mechanisms responsible for psychopathology [or mental disorders] in childhood and adolescence. The Conte Centers program is intended to support research demonstrating an extraordinary level of synergy, integration, and potential for advancing the state of the field; this program is intended only for projects that could not be achieved by using other, more standard grant mechanisms. The Conte Centers program also provides an opportunity to establish interdisciplinary and/or translational research experiences for individuals in pre- and postdoctoral training. 2009-08-25 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5285 This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR), encourages the submission of research grant applications from scientists who propose to study the factors that mediate initiation, use, and cessation of smokeless tobacco, to understand the relationship of smokeless tobacco with other tobacco products, and to develop methods for studying smokeless tobacco products and related behaviors in humans. The overall goal is to develop an evidence base to inform smokeless tobacco control efforts, and to develop effective ways to limit the spread and promote cessation of smokeless tobacco use. 2008-10-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5287 The purpose of this Funding Opportunity Announcement (FOA) issued by NICHD is to solicit applications to support a national program of mentored advanced career development and training in research for junior faculty in pediatric critical care medicine at research-intensive institutions. 2008-10-20 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5267 This funding opportunity announcement (FOA), issued by the National Cancer Institute, encourages research grant applications for projects designed to improve outcomes of smoking cessation in low-income adult populations within the United States. Despite significant progress in reducing the prevalence of smoking in the United States, smoking continues to represent a major threat to public health. In addition, decreases in smoking have not been consistent across the population and marked disparities exist, with smoking prevalence continuing to remain high among low-income adults. The long-term goal is to facilitate a significant reduction in smoking prevalence among low-income adults, thereby reducing the excess disease burden of tobacco use within these groups and decreasing the prevalence of smoking in the United States as a whole. This FOA is intended to support human research only. 2008-10-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5298 The National Institute of Diabetes and Digestive and Kidney Diseases on behalf of the National Institutes of Health Genes, Environment and Health Initiative solicits Exploratory/Developmental Clinical Research Grant (R21) applications from institutions/ organizations that propose a) clinical studies using information from genome-wide association or other genetic studies in common diseases; b) development and assessment of diagnostic, clinical trial, epidemiologic and risk-analytic tools for use in clinical research or practice; and c) cost-effectiveness studies of clinical applications of genetic information. Areas of interest include, but are not limited to: development of diagnostic or other risk-factor algorithms that incorporate genetic data; pilot interventional studies using findings from genetic studies of common diseases or outcomes related to genetic testing for variants identified in common diseases; pilot research on clinical modification of environmental factors known to interact with specific genes variants identified in common diseases; and cost-effectiveness studies. The proposed research must focus on using findings from genetic studies of common diseases with complex genetic etiology in clinical or public health settings. Through an R21 grant, this funding opportunity announcement will support efforts to produce data that may be useful or pivotal in eventually designing large-scale clinical trials or studies. 2008-10-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5264 This funding opportunity announcement (FOA), issued by the National Cancer Institute, encourages research grant applications for projects designed to improve outcomes of smoking cessation in low-income adult populations within the United States. Despite significant progress in reducing the prevalence of smoking in the United States, smoking continues to represent a major threat to public health. In addition, decreases in smoking have not been consistent across the population and marked disparities exist, with smoking prevalence continuing to remain high among low-income adults. The long-term goal is to facilitate a significant reduction in smoking prevalence among low-income adults, thereby reducing the excess disease burden of tobacco use within these groups and decreasing the prevalence of smoking in the United States as a whole. This FOA is intended to support human research only. 2008-10-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5255 This funding opportunity announcement (FOA) solicits Research Project (R01) grant applications from applicant organizations to develop theoretically grounded approaches to prevention of HIV infection and transmission that incorporate biobehavioral approaches in studies that are culturally appropriate. Biobehavioral approaches may be biomedical, or they may consist of behavioral interventions using biological markers of efficacy. Sociocultural appropriateness involves, at minimum, application of knowledge of the norms, beliefs and values of potential research subjects in varied contexts, and an appreciation of culture as dynamic. It is anticipated that such knowledge will improve both the quality and applicability of research among the diverse populations affected by the pandemic, in the US or abroad. Intervention and pre-intervention studies are welcomed, but descriptive ethnographic and epidemiological research is still needed in some areas. For example, descriptive research may delineate the impact of cultural variables on behaviors that impede or promote biological markers (e.g., seroconversion), lead to a better understanding of ethical concerns in biomedical preventive studies, or may illuminate as yet unrecognized issues concerned with adherence to a prevention interventions. Intervention studies should evaluate the efficacy of biomedical interventions, or of behavioral interventions that also use biological variables, in light of the sociocultural context. 2008-10-05 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5286 This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR), encourages the submission of research grant applications from scientists who propose to study the factors that mediate initiation, use, and cessation of smokeless tobacco, to understand the relationship of smokeless tobacco with other tobacco products, and to develop methods for studying smokeless tobacco products and related behaviors in humans. The overall goal is to develop an evidence base to inform smokeless tobacco control efforts, and to develop effective ways to limit the spread and promote cessation of smokeless tobacco use. 2008-10-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5264 The National Institute of Allergy and Infectious Diseases, National Institutes of Health, invites Exploratory/Developmental Research Project (R21) applications from institutions/organizations that propose to study immune defense mechanisms and immune regulation at mucosal surfaces, including the respiratory, gastrointestinal, and urogenital tracts. The goal is to gain new insights that will facilitate future development of vaccines and immunotherapies to protect mucosal surfaces from infection and inflammation. Investigators who have no prior history of receiving independent funding in this field are encouraged to apply. This funding opportunity announcement will support basic and applied research that contributes to understanding broadly applicable host mechanisms of mucosal immune defense. 2008-09-15 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5258 The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) invite research grant applications aimed at developing and or refinement of animal or ex vivo cell culture model systems for study of the neurologic complications of AIDS, with or without a history of drug or alcohol use. Recent advances in the development of the SIV model system highlight the power of animal model systems for study of the mechanisms underlying the pathology associated with lentiviral infection in the nervous system. These models will be key for developing therapeutic approaches for the treatment of patients suffering from NeuroAIDS and for understanding the basic biology of infection with HIV/AIDS. 2008-10-05 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5238 The National Institute on Deafness and Other Communication Disorders (NIDCD) invites grant applications using comprehensive systems biology approaches intended to restore lost auditory hair cells and their sensory function following damage to the inner ear from a variety of factors including disease, aminoglycosides, noise, and aging. Mechanism of Support: This funding opportunity announcement (FOA) will utilize the National Institutes of Health Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-176, that encourages applications under the R21. Funds Available and Anticipated Number of Awards: Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon application numbers, quality, duration, and costs of the applications received. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period: Budgets with direct costs up to $500,000 per year and project duration of up to 5 years may be requested. 2008-10-05 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5295 This funding opportunity announcement (FOA) is targeted toward supporting well-designed, investigator-initiated Phase III Definitive Clinical Trials (DCTs) to establish safe and effective treatments or interventions for communication disorders. A Phase III DCT proposed under this FOA should have the potential to provide a significant impact on clinical practice or public health policy if successful. It is expected that applicants for a Phase III DCT already have adequate preclinical and preliminary clinical data to support the Phase III DCT. Also, information necessary to address core design and clinical issues prior to the conduct of the Phase III DCT should have already been established, and a complete, detailed Manual of Procedures (MOP) has been developed. The MOP MUST be submitted as an appendix to the Phase III DCT application. The National Institute on Deafness and Other Communication Disorders Clinical Trial Planning Grant (R34) (PAR-08-203) and/or the NIDCD Phase I/II Preliminary Clinical Trial FOA (PAR-08-204) can be used to gather this information and prepare the MOP. 2008-10-05 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5294 The National Institute on Deafness and Other Communication Disorders is committed to identifying effective interventions for the treatment or prevention of communication disorders by supporting robust, well-designed, and well-executed clinical trials. Before a full scale Phase III Definitive Clinical Trial (DCT) (PAR-08-205) can be undertaken, earlier stage Phase I/II Preliminary Clinical Trials (PCT) are often required. This funding opportunity announcement is specifically targeted toward supporting studies that will provide the preliminary data that are necessary to address core scientific, design, and clinical issues prior to the conduct of the Phase III DCT. It is intended that these PCTs will serve to optimize the design of the eventual Phase III DCT and NOT address the definitive clinical question with lower power. 2008-10-05 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5284 This program provides 3 to 5 years of mentored career-development support to clinically trained faculty members in strong research environments to enable them to gain skills and experience in aging research under the guidance of a mentor or mentors and to establish an independent program of research in this field. It also includes an annual meeting that allows opportunities to partner with national mentors and fellow awardees. 2008-10-03 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5283 This funding opportunity announcement solicits (R01) grant applications from applicant organizations that propose to develop and pilot test innovative interventions to remediate age-related cognitive decline. These pilot tests are not expected to fulfill criteria for full-scale clinical trials but should help establish the feasibility and likely effect sizes of potential interventions. The interventions developed should be amenable for testing in a randomized clinical trial. 2008-10-03 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5278 This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Nursing Research (NINR), the National Institute of Child Health and Human Development (NICHD), and the Office of Behavioral and Social Sciences Research (OBSSR), encourages the submission of grant applications that propose hypothesis-driven projects exploring associations between the built environment, other contextual features of where people of all ages live and work and health behaviors related to energy balance. These projects should use population level data from health surveys and other large health studies. It is expected that the proposed projects will be designed to add/include contextual variables at diverse levels of geographic aggregation to such studies on behaviors that affect individual energy balance and thereby health. 2008-09-16 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5300 The purpose of this funding opportunity is to support research on: 1)causal factors explaining the current patterns observed in the careers of women in biomedical and behavioral science and engineering and variation across different subgroups and 2) the efficacy of programs designed to support the careers of women in these disciplines. Causal factors include individual characteristics, family and economic circumstances, disciplinary culture or practices, and features of the broader social and cultural context. Research on variation among underrepresented minority women and socioeconomically disadvantaged women is encouraged. 2008-09-21 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5228 The National Institute of Allergy and Infectious Diseases invites new or renewal applications from groups of two or more institutions to participate in the Clinical Trials in Organ Transplantation consortium, a cooperative investigative group that will conduct multisite clinical trials (Phase I, II, or III) or observational clinical studies with associated studies of immunologic mechanisms, in recipients of thoracic and abdominal organ transplants. Research supported under this funding opportunity announcement will focus on studying the immune-mediated pathologic processes associated with organ transplantation, with the goal of improving the long-term outcome of recipients of thoracic and abdominal organ transplants. 2008-09-22 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5229 The purpose of this funding opportunity announcement (FOA) is to support pilot clinical studies of medications for investigation as possible treatments for Substance Related Disorders (SRDs). Because the purpose of this FOA is to support pilot studies, preliminary studies are not required. This FOA does not support clinical studies of nicotine- or alcohol-related disorders, except as comorbid disorders with other SRDs. The National Institute on Drug Abuse (NIDA) expects to receive grant applications for clinical research on medications for which some theoretical or limited preclinical or clinical information exists for investigation as possible treatments of individual SRDs, combinations of them (i.e., cocaine and alcohol use, cocaine and cannabis use) or comorbid with other psychiatric disorders but which are not ready to be tested in a large and expensive randomized clinical trial. This FOA will not accept proposals that involve preclinical studies. NIDA will not accept applications testing medications that have already demonstrated safety and efficacy for the target disorder. Therefore, there must be a strong rationale for the medications proposed for testing, but no preclinical or clinical data are required or expected. 2008-09-23 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5272 The National Institute of General Medical Sciences (NIGMS) invites applications for National Centers for Systems Biology. The goal of the program is to promote institutional development of pioneering research, research training, and outreach programs focused on systems-level inquiries of biomedical questions within the NIGMS mission. The NIGMS supports fundamental inquiries focused on bioinformatics and computational biology, molecular and cell biology, biophysics, genetics and developmental biology, biochemistry, pharmacology, anesthesiology, and human physiology in the areas of trauma, burn, inflammation, and multi-organ failure. 2008-09-24 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5240 The purpose of the Seeding Collaborative Interdisciplinary Team Science program described in this announcement is to provide initial support to enable strong new investigative teams to form, and to foster preliminary research activities. It is anticipated that research teams receiving seeding support under this program will be well-positioned to compete for funds through the parent National Institute of Diabetes and Digestive and Kidney Diseases Collaborative Interdisciplinary Research Program in Diabetes, Endocrinology, and Metabolic Diseases solicitation (see PAR-08-182). 2008-09-25 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5271 The Outstanding New Environmental Scientist Award is intended to identify outstanding scientists who are in the early, formative stages of their careers and who intend to make a long term career commitment to research in the mission areas of the NIEHS and assist them in launching an innovative research program focusing on problems of environmental exposures and human biology, human pathophysiology and human disease. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5301 The National Institutes of Health invites applications that propose research to transform our understanding of the epigenetic contributions to human disease. Studies will characterize global (epigenome-wide) marks or features, and their possible interactions, in cells and tissues that are representative of various human disease states, conditions, or processes. Rather than solely advancing knowledge, transformation as defined in this funding opportunity announcement, is intended to change our fundamental understanding of human health and disease by creating a new paradigm or by disrupting an existing one. Unbiased epigenome-wide (global) mapping approaches must be used to identify marks in diseased, aged, or environmentally compromised human primary cells or tissues. Mammalian animal models are allowed in rare exceptions where human samples cannot be obtained for a given disease/condition of interest, but strong justification must be provided. Mapping the epigenome of normal cells will be permitted only as a control for mapping the epigenome of diseased or other aberrant cellular states. Studies may also include follow-up epigenetic approaches to reveal function or significance of target genomic regions or loci identified through the initial mapping. 2008-09-28 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5226 The purpose of this funding opportunity announcement is to solicit applications for research projects (R01) to develop models that forecast Medicare expenditures or provide insight into key aspects of the forecasting of Medicare expenditures (e.g., cost growth and population aging). 2008-09-29 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5269 This funding opportunity announcement (FOA) issued by the National Institute of Dental and Craniofacial Research solicits Research Project Grant (R01) applications from institutions/organizations that will elucidate the molecular mechanisms of resolution of acute and chronic inflammation and will develop novel multidisciplinary approaches for predictable control and patterning of tissue inflammatory microenvironments. Achieving the goals of this FOA will result in derivation of novel concepts and paradigms for promoting inflammation resolution, in overcoming tissue fibrosis and scarring, and in regenerating and reconstructing diseased and injured oral and craniofacial tissues. Toward these goals, this FOA will require interdisciplinary and multidisciplinary research that integrate advances in disciplines such as cell and developmental biology, stem cell biology, and immunology, with advances in chemistry, pharmacology, and bioengineering. Use of the multiple principal investigator application format is strongly encouraged for this FOA. 2008-09-30 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5270 This funding opportunity announcement (FOA) issued by the National Institute of Dental and Craniofacial Research solicits exploratory/developmental Research Grant (R21) applications from institutions/organizations that will elucidate the molecular mechanisms of resolution of acute and chronic inflammation, and will initiate development of novel multidisciplinary approaches for predictable control and patterning of tissue inflammatory microenvironments. This FOA will support early stages of high risk–high impact research that will lead to breaking new ground or extend previous discoveries toward significant advances in our understanding of the mechanisms of inflammation resolution and tissue regeneration and will lead to development of clinically relevant approaches for promoting inflammation resolution, for overcoming tissue fibrosis and scarring, and for regenerating and reconstructing diseased and injured oral and craniofacial tissues. Toward these goals, this FOA encourages exploratory and developmental research that utilizes interdisciplinary and multidisciplinary approaches that integrate advances in disciplines such as cell and developmental biology, stem cell biology, and immunology, with advances in chemistry, pharmacology, and bioengineering. Use of the multiple principal investigator application format is strongly encouraged for this FOA. Long-term projects or projects designed to increase knowledge in the ongoing area of investigation will not be considered under this FOA. 2008-09-30 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5236 The National Institute of Justice's (NIJ's) Graduate Research Fellowship Program is an annual program that provides assistance to universities for dissertation research support to outstanding doctoral students undertaking independent research on issues related to crime and justice. Students from any academic discipline may propose original research that has direct implications for criminal justice in the United States. NIJ encourages a variety of approaches and perspectives in its research programs. NIJ awards these fellowships in an effort to encourage promising doctoral students in the application of critical and innovative thinking to pressing criminal justice problems. 2008-11-21 http://grantsnet.org/search/pgm_info.cfm?pgm_id=2097 These two-year fellowships help attract the nation's best scientific talent to careers in lymphoma and allow them to pursue promising leads under the guidance of a Sponsor. Applicants must be affiliated with an institution in the U.S. or Canada. Up to 10 fellowships may be awarded, each at $50,000 in year one, and $55,000 in year two. 2008-09-10 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5203 The goal of the Lymphoma Research Foundation's (LRF's) Follicular Lymphoma (FL) Research Initiative is to develop novel therapeutic strategies for the treatment of FL. LRF is seeking proposals that advance the understanding of the human biology of FL or that verify molecular targets for FL therapeutics. LRF is awarding two grants for this special research initiative, each at a maximum of $250,000 per year for 3 years. 2008-09-10 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5204 The Lymphoma Research Foundation (LRF) is also seeking proposals for correlative clinical studies in follicular lymphoma (FL). Applications to this initiative must be adjunct to a major FL research project and work in the clinical setting or with primary FL patient samples. LRF is awarding two correlative clinical study awards, each at a maximum of $125,000 per year for 3 years. 2008-09-10 http://grantsnet.org/search/pgm_info.cfm?pgm_id=2437 This 3-year program (now with recently expanded eligibility) funds training of clinicians who will participate in developing new therapeutics and diagnostic tools for lymphoma. Clinicians will be trained to design and administer clinical studies and to take on primary responsibility for trial design, protocol development, Institutional Review Board submission, and publication. A career development plan and the commitment of a mentor are required as part of the grant application. Up to three career development awards will be awarded, each at a maximum of $75,000 per year for 3 years. Applicants must be licensed in the United States or Canada. 2008-09-10 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5251 The National Science Foundation (NSF) invites investigators at U.S. organizations to submit proposals for projects that will contribute to the further development of the Arctic Observing Network (AON) and enable the Study of Environmental Arctic Change (SEARCH). Compared with much of the rest of Earth, the Arctic is a data-sparse region where large, rapid and systemwide environmental change is occurring. The goal of AON is to enhance the environmental-observing infrastructure required for the scientific investigation of Arctic environmental change and its global connections. This solicitation invites proposals for the following activities: continuation of existing NSF-supported AON projects; the initiation of new AON projects; and projects that address environmental-observing system coverage, design, and optimization. AON encompasses physical, biological, and human observations, including indigenous knowledge of the land, ocean, and atmosphere (to a maximum altitude of ~90 km, i.e., the top of the mesosphere). Proposals must include a scientific rationale that includes an explanation as to why the proposed activity, data (including frequency and duration of observations), and geographic location are essential to research that will advance the understanding of Arctic environmental change. Proposals for the research, e.g., data analysis, data synthesis, process studies, and computer modeling, that will lead to understanding of Arctic environmental change will not be considered. 2008-09-30 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5252 The Science and Technology Centers (STCs): Integrative Partnerships program supports innovative, potentially transformative, complex research and education projects that require large-scale, long-term awards. STCs conduct world-class research through partnerships among academic institutions, national laboratories, industrial organizations, and/or other public/private entities, and via international collaborations, as appropriate. They provide a means to undertake important investigations at the interfaces of disciplines and/or fresh approaches within disciplines. STC investments support the National Science Foundation's vision of advancing discovery, innovation, and education beyond the frontiers of current knowledge, and empowering future generations in science and engineering. 2008-09-30 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5224 The Nano and Bio Mechanics program supports fundamental research in biomechanics and nanomechanics. Research on biomechanics focuses on the mechanical properties and behavior of biological materials and structures, including cells, tissue, muscles, bones, and prosthetic implants. Research on nanomechanics focuses on the unique properties of nanoscale particles and microstructural features and their effects on the macroscopic mechanics and properties of materials, surfaces, and structures that contain them. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5221 The Nanomanufacturing program supports research and education on manufacturing at the nanoscale and the transfer of research results in nanoscience and nanotechnology to industrial applications. The program emphasizes a systems approach to scale-up of nanotechnology for high-rate production, reliability, robustness, yield and cost, and promotes integration of nanostructures to functional micro devices and meso/macroscale systems. Special emphases are on environmental, health, and societal aspects of nanotechnology and nanomanufacturing. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5222 The Operations Research program supports research leading to advances in the science of models and algorithms that are applicable to the operation and optimization of large-scale systems. Topic areas include advances in the theory of optimization and heuristic approaches to NP-hard optimization problems, simulation and stochastic modeling, and on the development of novel, enterprisewide models requiring advanced high-end computing. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5260 The Control Systems program supports innovative research on control theory and control technology driven by real-life applications. The program accepts proposals on transformative research in established topic areas such as model-based control. However, the program emphasis is on paradigm-shifting ideas for control strategies that may be inspired by nature, unconventional applications, and the combined role of feedback and uncertainty in systems that incorporate large numbers of sensors and actuators. New sensor and actuator concepts that integrate feedback and signal processing to achieve a sensing or actuation objective are also funded. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5261 The GEOMM program supports fundamental research on the mechanics and engineering properties of geologic materials including the mechanical properties of soil and rock, mechanically stabilized and biologically modified soil, and on natural processes, such as hydraulic, biological and thermal, that affect the behavior of these materials. Research on soil-structure interaction and liquefaction are also funded by the program. Support is provided for theoretical studies, constitutive and numerical modeling, and laboratory, centrifuge, and field testing. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5218 The Sensors and Sensing Science program supports research on methods to acquire and use sensor data on civil, mechanical, and manufacturing systems. The program supports fundamental research on advanced actuators, sensors, wireless sensor networks, new materials and concepts for sensing applications, power generation, and energy supply for sensors and sensing systems. Also of interest is research on the strategic incorporation of sensors into both natural and engineered systems to achieve effective data acquisition and on processing and transmission of sensor data. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5274 The National Science Foundation Astronomy and Astrophysics Postdoctoral Fellowships provide an opportunity for highly qualified recent doctoral scientists to carry out an integrated program of independent research and education. Fellows may engage in observational, instrumental, theoretical, laboratory, or archival data research in any area of astronomy or astrophysics, in combination with a coherent educational plan for the duration of the fellowship. The program supports researchers for a period of up to 3 years with fellowships that may be taken to eligible host institution(s) of their choice. The program is intended to recognize early-career investigators of significant potential and to provide them with experience in research and education that will establish them in positions of distinction and leadership in the community. 2008-10-08 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5207 The plasma physics program funds research in the fundamental physics of plasmas. Research areas include plasma turbulence and shocks, turbulent and nonlocal, collisional transport with and without strong magnetic fields, non-neutral plasmas, cold plasmas, strongly coupled and dusty plasmas, laser-plasma interactions, ultrashort pulse and/or ultraintense laser plasma interactions, high-energy-density plasmas, and low-temperature plasmas. Both theoretical and experimental research is included. Note that there is often coordination between the Physics Division and other organizations within the Mathematical and Physical Science Directorate as well as in the Engineering and Geophysical Sciences Directorates to coreview proposals that are plasma related but cross disciplinary boundaries. 2008-10-22 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5250 This solicitation seeks proposals in cross-cutting areas that are scientifically timely and that benefit from the intellectual contributions of researchers with expertise in a number of computing fields and/or subfields. The cross-cutting programs for fiscal years 2009 and 2010 are: data-intensive computing; network science and engineering; and trustworthy computing. The full descriptions of these programs can be found in the II. Program Description section of this solicitation. 2008-10-31 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5233 In many areas of research, a key to making advances is the ability of scientists and engineers to manipulate extremely large quantities of information. Examples include: numerical simulation and modeling; the analysis of very large data sets, whether generated by new generations of scientific instrumentation or by numerical models; and the mining of a wide range of collections of digital artifacts. At the largest scales, the resources needed to work with huge volumes of digital information are expensive and scarce. In recent years, the research community, with support from the National Science Foundation (NSF), has developed the TeraGrid as a way of providing wide access to these scarce, expensive resources. The need for such widely shared national resources continues to grow, and as the currently funded phase of TeraGrid operations approaches its close, NSF is inviting innovative proposals for a new infrastructure to deliver the next generation of high-end digital services, as national resources, that will provide researchers and educators with the capability to work with extremely large amounts of digitally represented information. 2008-11-04 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5259 The statistics program supports research in statistical theory and methods, including research in statistical methods for applications to any domain of science and engineering. The theory forms the base for statistical science. The methods are used for stochastic modeling and for the collection, analysis, and interpretation of data. The methods characterize uncertainty in the data and facilitate advancement in science and engineering. The program encourages proposals ranging from single-investigator projects to interdisciplinary team projects. 2008-11-07 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5235 The National Science Foundation's 5-year goal for high-performance computing (HPC) is to enable petascale science and engineering through the deployment and support of a world-class HPC environment comprising the most capable combination of HPC assets available to the academic community. By the year 2010, the petascale HPC environment will enable investigations of computationally challenging problems that require computing systems capable of delivering sustained performance approaching 1015 floating point operations per second (petaflops) on real applications that consume large amounts of memory and/or that work with very large data sets. Among other things, researchers will be able to perform simulations that are intrinsically multiscale or that involve the simultaneous interaction of multiple processes. HPC resource providers--those organizations willing to acquire, deploy, and operate HPC systems in service to the broad science and engineering research and education community--play a key role in the provision and support of a national HPC environment. 2008-11-28 http://grantsnet.org/search/pgm_info.cfm?pgm_id=5200 The Computer and Information Science and Engineering (CISE) Computing Research Infrastructure (CRI) program drives discovery and learning in the computing disciplines by supporting the creation, enhancement, and operation of world-class computing research infrastructure. Further, through the CRI program CISE seeks to ensure that individuals from a diverse range of academic institutions, including minority-serving and predominantly undergraduate institutions, have access to such infrastructure. The CRI program supports two classes of awards: Institutional Infrastructure awards support either the creation of new computing research infrastructure or the enhancement of existing computing research infrastructure to enable world-class research and education opportunities at the awardee and collaborating institutions. Community Infrastructure (CI) awards support the planning for computing research infrastructure, or the creation of new computing infrastructure, or the enhancement of existing computing research infrastructure to enable world-class research and education opportunities for broadly based communities of researchers and educators that extend well beyond the awardee institutions. Furthermore, CI awards support the operation of such infrastructure, ensuring that awardee institutions are well-positioned to provide a high quality of service to community researchers and educators expected to use the infrastructure to realize their research and education goals. 2008-09-22 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=5245 The Network for Earthquake Engineering Simulation (NEES) is a National Science Foundation–supported shared resource of experimental facilities and cyberinfrastructure for research and education to advance knowledge discovery and innovation to reduce losses from earthquakes. The NEES experimental infrastructure comprises a network of 15 earthquake engineering equipment sites, located at universities across the United States, available for testing on-site, in the field, or through telepresence. The NEES equipment sites include shake tables, geotechnical centrifuges, a tsunami wave basin, unique large-scale testing laboratories, and mobile and permanently installed field equipment. The NEES cyberinfrastructure connects the equipment sites, via Internet2, and provides data curation and a curated central data repository; telepresence; simulation, computational, data visualization, and collaborative tools; hybrid (coupled computational and physical) simulation and multisite hybrid simulation capabilities; user support services; middleware; and a cybersecurity framework. 2008-09-03 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=1102 The goal of this program is to promote continued excellence in biomedical research and to develop research in Latin America by supporting outstanding, competitively selected biomedical scientists who will receive advanced training in the United States and return home to teach and undertake research. 2008-10-01 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=4257 In 2008, the Smith Family New Investigator Awards Program was changed to the Smith Family Awards for Excellence in Biomedical Research, and each award was increased to $300,000 over 3 years. The previous focus on a specific disease category has now been eliminated and applications will be accepted from all fields of biomedical science. In addition, projects that focus on biomedical research may be submitted from departments of physics, chemistry, and engineering. The maximum number of submissions remains at two applications per institution. 2008-09-11 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=4212 The Abe Fellowship is designed to encourage international multidisciplinary research on topics of pressing global concern. The program seeks to foster the development of a new generation of researchers who are interested in policy-relevant topics of long-range importance and who are willing to become key members of a bilateral and global research network built around such topics. Applications are welcome from scholars and nonacademic research professionals. Funding for the program is provided by the Japan Foundation Center for Global Partnership. 2008-09-01 http://grantsnet.org/search/pgm_info.cfm?pgm_id=2824 The Eli and Edythe Broad Foundation created the Broad Medical Research Program (BMRP) for Inflammatory Bowel Disease (IBD) Grants in 2001. BMRP will provide rapid funding for up to 2 years for basic or clinical IBD research projects that: (a) are innovative; (b) are in the early stages of exploration; (c) will improve diagnosis, therapy, or prevention of IBD; and (d) will lead to longer term funding by more traditional granting agencies. Proposals must be clinically relevant and must benefit patients with IBD. Proposals in the basic sciences should have clear relevance to findings and observations in IBD patients. Basic and clinical investigators, scientists not currently working in IBD, and interdisciplinary teams are encouraged to apply. 2008-12-31 http://www.grantsnet.org/search/pgm_info.cfm?pgm_id=2947 The United Mitochondrial Disease Foundation is seeking new, innovative research to continue its mission to find cures and better treatments for mitochondrial diseases. Proposals will be considered in basic science and clinical areas and must fall under at least one of the following categories: seed money for new researchers, postdoctoral fellowship, or new area of research for experienced investigators. 2008-09-17